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Campylobacter reactive arthritis: a systematic review.
Janet E Pope1, Adriana Krizova, Amit X Garg
1Division of Rheumatology, Department of Medicine, The University of Western Ontario, Ontario, Canada. janet.pope@sjhc.london.on.ca
Seminars in Arthritis and Rheumatism
|March 16, 2007
Summary
Campylobacter-associated reactive arthritis (ReA) incidence varies widely, potentially affecting 1-5% of infected individuals. Long-term outcomes and chronic ReA impact remain largely unknown.
Area of Science:
- Rheumatology
- Infectious Diseases
- Epidemiology
Background:
- Reactive arthritis (ReA) is a form of spondyloarthropathy.
- Campylobacter infection is a known trigger for ReA.
Purpose of the Study:
- To review the existing literature on the epidemiology of Campylobacter-associated reactive arthritis.
Main Methods:
- A comprehensive literature search was conducted using Medline (PubMed) from 1966 to 2006.
- Keywords included various terms related to reactive arthritis, spondyloarthropathy, and Campylobacter infection epidemiology.
Main Results:
- The incidence of Campylobacter-associated ReA is estimated between 1-5% of infected individuals.
- Annual incidence rates per 100,000 were reported as 4.3 for Campylobacter and 1.3 for Shigella.
- Data on the duration of acute ReA is variable, and the long-term impact of chronic ReA is largely unknown.
Conclusions:
- Wide variations in reported incidence and prevalence are attributed to differences in case ascertainment, diagnostic criteria, and population factors.
- HLA-B27 association and inflammatory back involvement appear uncommon at the population level.
- Long-term sequelae of Campylobacter-associated ReA require further investigation, with an estimated 5% potentially developing chronic or relapsing symptoms.
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