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Published on: July 14, 2023
OspC phylogenetic analyses support the feasibility of a broadly protective polyvalent chimeric Lyme disease vaccine
Christopher G Earnhart1, Richard T Marconi
1Department of Microbiology and Immunology, Center for the Study of Biological Complexity, Medical College of Virginia at Virginia Commonwealth University, Richmond, VA 23298-0678, USA.
Abstract:
Using available Borrelia outer surface protein C (OspC) sequences, a phylogenetic analysis was undertaken to delineate the number of antigenic domains required for inclusion in a broadly protective, chimeric, OspC-based Lyme disease vaccine. The data indicate that approximately 34 would be required and that an OspC-based vaccinogen is feasible.
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