Related Experiment Video
Updated: Jul 16, 2026
06:43
Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management
Published on: November 21, 2017
[Therapeutic hypothermia and acid-base management]
1Klinik für Anästhesiologie, Intensiv-, Notfallmedizin und Schmerztherapie (Campus Bethel), Evangelisches Krankenhaus Bielefeld gGmbH (EvKB), Burgsteig 13, 33617 Bielefeld. Friedhelm.Bach@evkb.de
Der Anaesthesist
|March 16, 2007
Summary
Therapeutic hypothermia is beneficial for acute neurological conditions but requires expertise. Optimal management of acid-base balance, using pH-stat or alpha-stat, needs further research for evidence-based decisions.
Area of Science:
- Neurology
- Physiology
- Critical Care Medicine
Context:
- Moderate hypothermia is increasingly used for acute neurological injuries.
- Its application demands significant resources and expertise in hypothermia physiology.
- Managing physiological homeostasis, especially acid-base balance, is critical.
Purpose:
- To discuss the challenges and considerations in applying therapeutic hypothermia.
- To explore the two main acid-base management strategies: pH-stat and alpha-stat.
- To highlight the need for further research to guide clinical decisions.
Summary:
- Therapeutic hypothermia presents challenges due to resource needs and physiological complexities.
- Two acid-base management approaches, pH-stat and alpha-stat, exist but lack comparative clinical data.
- Experimental data suggest an illness-specific approach may be beneficial.
Impact:
- Underscores the need for specialized skills in managing hypothermia's adverse effects.
- Emphasizes the importance of adapting homeostasis parameters, particularly acid-base balance.
- Calls for prospective studies to establish evidence-based guidelines for pH and pCO2 management.
More Related Videos
Related Concept Videos
01:22Methods of reducing fever
The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
Pharmacological Methods of Reducing Fever:
01:29Decreased Body Temperature
A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by sustained extreme cold exposure, and severe...
01:29Acute Respiratory Failure-V
The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Ensure that patients are monitored continuously for their response to therapy, including changes in...
01:25Acid-Base Balance
The human body maintains a narrow pH range regulated through acid-base balance. This balance is crucial as changes in the hydrogen ion concentration can disrupt cell membrane stability, alter protein structures, and change enzyme activities. The normal pH of arterial blood is 7.4, venous blood and interstitial fluid is 7.35, and intracellular fluid averages 7.0.
When the pH of arterial blood rises above 7.45, it results in a condition called alkalosis. Conversely, a drop below 7.35 leads to...
When the pH of arterial blood rises above 7.45, it results in a condition called alkalosis. Conversely, a drop below 7.35 leads to...
01:25Cardiopulmonary Resuscitation IV: Pharmacological Management
Pharmacologic intervention is crucial in treating cardiac arrest patients during ACLS or Advanced Cardiovascular Life Support. The ACLS algorithms guide the administration of specific drugs based on the patient's cardiac arrest rhythm, which includes pulseless ventricular tachycardia (VT), ventricular fibrillation (VF), asystole, and pulseless electrical activity (PEA).EpinephrineIndication: Epinephrine is the first-line drug for all cardiac arrest rhythms.Mechanism of Action: Epinephrine...
01:25Increased Body Temperature
A body temperature above 38°C (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in response to an infection or illness.