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Methodology for Establishing a Community-Wide Life Laboratory for Capturing Unobtrusive and Continuous Remote Activity and Health Data
Published on: July 27, 2018
Development of a micro-ESR system with potential for in-home use
Sarah E Douglas1, Tim R Randolph
1Department of Clinical Laboratory Science, Doisy College of Health Sciences, Saint Louis University, 3437 Caroline Street, St. Louis, MO 63104-1111, USA.
Summary
Researchers developed a micro-erythrocyte sedimentation rate (ESR) system for home use. Three of four tested micro-ESR methods showed acceptable correlation with the Westergren ESR, indicating potential for self-administration.
Area of Science:
- Clinical Chemistry
- Hematology
- Point-of-Care Diagnostics
Background:
- The erythrocyte sedimentation rate (ESR) is a common blood test for inflammation.
- Current ESR methods require laboratory equipment and trained personnel.
- A self-administered micro-erythrocyte sedimentation rate (ESR) system using capillary blood could improve patient accessibility.
Purpose of the Study:
- To develop and evaluate micro-erythrocyte sedimentation rate (ESR) systems for potential home use.
- To assess the correlation of micro-ESR methods with the standard Westergren ESR method.
Main Methods:
- Four micro-ESR systems (micro-hematocrit tube, S/P capillary blood gas tube, Natelson tube, Caraway tube) were evaluated.
- Blood samples were standardized for hematocrit and fibrinogen levels to simulate normal and accelerated ESR.
- Micro-ESR results were compared to the Westergren ESR method using Pearson's r correlation.
Main Results:
- Correlation coefficients (r) with the Westergren ESR method were: S/P tube (0.808), Caraway tube (0.797), Natelson tube (0.719), and micro-hematocrit tube (0.655).
- Three of the four micro-ESR systems demonstrated acceptable correlation coefficients.
Conclusions:
- The S/P tube, Caraway tube, and Natelson tube show promise for a capillary-based micro-ESR system.
- These micro-ESR methods have the potential for self-administration by patients at home, improving convenience and accessibility.
