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Updated: Jul 16, 2026
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Fumaric acid esters in the management of severe psoriasis
1City of Dublin Skin and Cancer Hospital, Dublin, Ireland. lbrewer2004@yahoo.co.uk
Background:
Fumaric acid esters (FAEs) offer an effective alternative to patients with psoriasis in whom other systemic agents are contraindicated or have failed.
Objective:
We assessed the efficacy and side effect profile of FAEs in a group of patients with psoriasis.
Methods:
A retrospective study was carried out on patients treated with FAEs over 21 months. Information was gathered from patients' notes. Dosage, response and side effects were recorded.
Results:
In total, 31 patients were included. The mean age was 46.8 years. All patients had been treated with other modalities and 61.5% had received previous systemic treatment. There was good to excellent response in 58.6% of patients. Subjective side-effects were common (87.1%), and lymphopenia occurred in 61.3%. The drug was not tolerated by one-fifth of patients.
Conclusion:
The relatively low toxicity and absence of hepatotoxicity makes FAEs a reasonable first-line systemic treatment in selected patients with difficult psoriasis.
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