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Updated: Jul 16, 2026
07:44
A Porcine Model of Acute Autologous Pulmonary Embolism
Published on: September 6, 2024
Liver dysfunction in patients with acute pulmonary embolism.
Sahin Aslan1, Mehmet Meral, Metin Akgun
1Department of Emergency Medicine, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
Summary
Liver injury markers are altered in patients with acute pulmonary embolism (PE). Higher transaminase and bilirubin levels, along with lower albumin, correlate with severe hypoxemia and massive PE.
Area of Science:
- Cardiology
- Hepatology
- Pulmonology
Background:
- Liver injury is documented in cardiac and respiratory failure.
- Liver injury in acute pulmonary embolism (PE) remains understudied.
Purpose of the Study:
- To investigate liver injury in patients diagnosed with acute PE.
- To correlate liver enzyme abnormalities with PE severity and patient characteristics.
Main Methods:
- Retrospective review of 107 acute PE patients.
- Categorization based on hypoxemia severity, PE classification, pre-existing conditions, and right ventricle dysfunction.
- Comparison of serum liver enzyme levels across patient groups.
Main Results:
- Elevated transaminases and bilirubin, with decreased albumin, observed in severe hypoxemia.
- Significant negative correlations found between hepatic markers and oxygenation levels (P(a)O(2), %S(a)O(2)).
- Higher AST and ALT levels in massive PE; lower albumin in patients with right ventricle dysfunction.
Conclusions:
- Abnormal liver function tests (LFTs) present a mixed pattern in acute PE.
- Hypoxemia severity and PE classification are associated with specific LFT abnormalities.
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