Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antifungal Agents01:15

Antifungal Agents

29
Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to...
29
Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

695
Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
695

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Toxoplasmosis meets the World Health Organization criteria for a neglected tropical disease.

PLoS neglected tropical diseases·2026
Same author

Systematic review of the incidence of microbial keratitis following corneal transplantation for corneal endothelial decompensation.

The British journal of ophthalmology·2026
Same author

Macrophage Extracellular Vesicles: Therapeutic Strategies for Corneal Fibrosis in Rare Diseases.

Biomolecules·2026
Same author

Beyond emotions: Social cognitive predictors of COVID-19 vaccination intentions before and after vaccine roll-out.

PLOS global public health·2026
Same author

Diabetic retinopathy screening in Australian general practice: persistently low uptake despite national guidelines and equity initiatives.

Journal of diabetes and metabolic disorders·2025
Same author

Bacterial detection with electrochemical, SERS, and electrochemical SERS sensors.

The Analyst·2025

Related Experiment Video

Updated: Mar 25, 2026

A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice
07:00

A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice

Published on: October 5, 2018

11.2K

Fungal keratitis in Melbourne.

Prashant Bhartiya1, Mark Daniell, Marios Constantinou

  • 1Centre for Eye Research Australia, University of Melbourne, Mellbourne, Victoria, Australia.

Clinical & Experimental Ophthalmology
|March 17, 2007
PubMed
Summary

This study details fungal keratitis cases in Melbourne, Australia. Candida albicans was the most frequent cause, with ocular trauma and steroid use being significant risk factors.

More Related Videos

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.6K
Techniques for Processing Eyes Implanted With a Retinal Prosthesis for Localized Histopathological Analysis
12:01

Techniques for Processing Eyes Implanted With a Retinal Prosthesis for Localized Histopathological Analysis

Published on: August 2, 2013

20.4K

Related Experiment Videos

Last Updated: Mar 25, 2026

A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice
07:00

A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice

Published on: October 5, 2018

11.2K
A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.6K
Techniques for Processing Eyes Implanted With a Retinal Prosthesis for Localized Histopathological Analysis
12:01

Techniques for Processing Eyes Implanted With a Retinal Prosthesis for Localized Histopathological Analysis

Published on: August 2, 2013

20.4K

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Microbiology

Background:

  • Fungal keratitis presents a significant challenge in eye care.
  • Understanding its clinical and microbiological spectrum is crucial for effective management.

Purpose of the Study:

  • To describe the clinical and microbiological characteristics of fungal keratitis.
  • To identify predisposing factors and outcomes in Melbourne, Australia.

Main Methods:

  • Retrospective review of patients with fungal keratitis.
  • Data collected included demographics, risk factors, clinical presentation, management, and microbiological findings.

Main Results:

  • 56 patients with fungal keratitis were analyzed.
  • Major predisposing factors included ocular trauma (37.1%) and chronic steroid use (31.4%).
  • Candida albicans (37.2%) was the most common isolate, followed by Aspergillus (17.1%) and Fusarium (14.3%).

Conclusions:

  • Fungal keratitis in Melbourne shows a high incidence of Candida albicans infections.
  • Prior steroid use was noted in a significant proportion of patients.
  • Findings contrast with global reports, highlighting regional variations.