Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Non-coding sequence retrieval system for comparative genomic analysis of gene regulatory elements.

Sung Tae Doh1, Yunyu Zhang, Matthew H Temple

  • 1Biomedical Engineering Department, Rutgers University, 599 Taylor Road, Piscataway, NJ 08854, USA. sungtae@rci.rutgers.edu <sungtae@rci.rutgers.edu>

BMC Bioinformatics
|March 17, 2007
PubMed
Summary

A new web-based Non-Coding Sequences Retrieval System (NCSRS) facilitates the study of gene regulatory elements. This bioinformatics tool enables quick retrieval of non-coding and coding sequences from multiple species for enhanced genomic analysis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adiposity Mediates the Association of Objectively Measured Physical Activity with Cardiorespiratory Fitness in Children.

Childhood obesity (Print)·2020
Same author

The Expression of VEGF and CD31 in Endometrial Lesions and Its Associations with Blood Flow Parameters of Transvaginal 3D Power Doppler Ultrasonography: A Preliminary Study.

Cancer management and research·2020
Same author

Sclerosing pneumocytoma mixed with a columnar clear cell adenoma and a typical carcinoid: case report and review of literature.

International journal of clinical and experimental pathology·2020
Same author

Predictive Nomogram for Severe COVID-19 and Identification of Mortality-Related Immune Features.

The journal of allergy and clinical immunology. In practice·2020
Same author

Stimuli-Responsive Biomass Cellulose Particles Being Able to Reversibly Self-Assemble at Fluid Interface.

Frontiers in chemistry·2020
Same author

Targeting 14-3-3ζ Overcomes Resistance to Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors in Lung Adenocarcinoma via BMP2/Smad/ID1 Signaling.

Frontiers in oncology·2020

Area of Science:

  • Genomics
  • Bioinformatics
  • Molecular Biology

Background:

  • Genome sequencing advances understanding of biological mechanisms in health and disease.
  • Non-coding genomic regions, particularly gene regulatory elements like enhancers, are crucial but understudied.
  • Analyzing conserved regulatory elements across species presents significant challenges.

Purpose of the Study:

  • To develop a centralized, web-based system for efficient retrieval of non-coding sequences.
  • To facilitate multi-gene queries and analysis of gene regulatory elements.
  • To provide a user-friendly bioinformatics tool accessible via the internet.

Main Methods:

  • Development of a web-based bioinformatics tool, the Non-Coding Sequences Retrieval System (NCSRS).

Related Experiment Videos

  • Integration of data from multiple sources into a single, accessible interface.
  • Implementation of a system requiring only internet access, with no software installation.

    • Main Results:

    • The Non-Coding Sequences Retrieval System (NCSRS) enables fast and convenient retrieval of both non-coding and coding sequences.
    • The system supports queries related to specific genes or sets of genes across multiple species.
    • NCSRS offers a user-friendly web interface consolidating diverse genomic resources.

    Conclusions:

    • The NCSRS is a valuable resource for researchers studying gene regulatory elements in non-coding genomic regions.
    • Its unique features support comparative genomics and the analysis of regulatory elements.
    • The web-based application is publicly accessible at http://cell.rutgers.edu/ncsrs/.