Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Harnessing genetically engineered mouse models for preclinical testing.

Ana I Robles1, Lyuba Varticovski

  • 1Laboratory of Human Carcinogenesis, Center for Cancer Research, NCI, NIH, 37 Convent Drive, Room 3060, Bethesda, MD 20892, United States.

Chemico-Biological Interactions
|March 17, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integrated proteogenomic and metabolomic profiling of acute myeloid leukemias to identify molecular subtypes and associated therapy targets.

Nature cancer·2026
Same author

Navigating luminal heterogeneity: etiology-based proteogenomic subtyping for targeted treatment strategies in breast cancer.

Molecular cancer·2026
Same author

Artificial intelligence in cancer diagnostics: a primer for clinicians and scientists.

Journal of the National Cancer Institute·2026
Same author

A 15-layer multi-omics analysis of gastric cancer ecotypes provides therapeutic insights.

Cell reports. Medicine·2026
Same author

Integrative analysis of lung adenocarcinoma across diverse ethnicities and exposures.

Cancer cell·2025
Same author

Proteogenomic analysis of the CALGB 40601 (Alliance) HER2+ breast cancer neoadjuvant trial reveals resistance biomarkers.

Cell reports. Medicine·2025
Same journal

AMPK Activation by AICAR Mitigates Hypoxic Corneal Damage Through Rebuilding Energy and Metabolic Homeostasis.

Chemico-biological interactions·2026
Same journal

Interactions-Guided Blueprint of Acetylcholinesterase Binding: A Review on Structural and Molecular Determinants.

Chemico-biological interactions·2026
Same journal

Diazepam induces mitotic defects and cytotoxicity through modulation of tubulin and Eg5.

Chemico-biological interactions·2026
Same journal

Epigallocatechin-3-gallate, L-theanine and theophylline abolish high-glucose-induced renal cell senescence and subsequent epithelial-mesenchymal transition and fibroblast activation via SIRT1/PGC-1α axis: Implications for diabetic kidney disease.

Chemico-biological interactions·2026
Same journal

TCEP Induces Liver Injury Through Suppression of the PI3K/AKT Axis: Integrated Evidence from Epidemiology, Network Toxicology, and In Vivo Validation.

Chemico-biological interactions·2026
Same journal

Toxicity assessment of three emerging bisphenols (BPA, BPAP and BPC) and their binary mixtures in an advanced in vitro 3D HepG2 cell model.

Chemico-biological interactions·2026
See all related articles

Genetically engineered mouse models offer better cancer therapy testing than traditional xenografts. Adapting these models through transplantation can improve preclinical drug development and clinical trial success.

Area of Science:

  • Oncology
  • Preclinical Cancer Research
  • Translational Medicine

Background:

  • Traditional xenograft models show low predictive power for human cancer drug responses.
  • Genetically engineered mouse models (GEMMs) better recapitulate cancer molecular pathways.

Purpose of the Study:

  • To review the advantages and limitations of GEMMs for cancer therapy testing.
  • To propose solutions for adapting GEMMs for broader preclinical use.
  • To guide the development of new GEMMs for cancer research.

Main Methods:

  • Discussion of advantages and limitations of GEMMs.
  • Exploration of tumor transplantation techniques for GEMMs.
  • Comparative molecular analysis of mammary tumors from MMTV-Polyoma Middle-T antigen and MMTV-wnt1 models.

Related Experiment Videos

Main Results:

  • GEMMs offer improved biological systems for studying cancer progression.
  • Transplantation of GEMM tumors into naïve recipients is a plausible adaptation strategy.
  • Comparative molecular analysis aids in validating models and identifying clinical correlates.

Conclusions:

  • GEMMs hold significant promise for enhancing preclinical cancer therapy testing.
  • Adapting GEMMs via transplantation can increase their utility in drug development.
  • Further development and validation of GEMMs are crucial for advancing cancer research.