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An In Vitro Model for Studying Tau Aggregation Using Lentiviral-mediated Transduction of Human Neurons
Published on: May 23, 2019
A mouse model to study tau pathology related with tau phosphorylation and assembly
Tobias Engel1, José J Lucas, Félix Hernández
1Centro de Biología Molecular "Severo Ochoa", CSIC/UAM, 28049 Madrid, Spain.
Journal of the Neurological Sciences
|March 17, 2007
Abstract:
The role of tau phosphorylation and tau aggregation in the pathology of a transgenic mouse model that overexpresses GSK-3beta and FTDP-17 tau has been analyzed. In that model we have suggested a possible role for tau phosphorylation, but not for tau aggregation, in the cognitive impairment found in the transgenic mouse.
