Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human adrenal cortex hyperfunction due to LH/hCG.

Harold E Carlson1

  • 1Department of Medicine, Endocrinology Division, HSC T15-060, Stony Brook University, Stony Brook, NY 11794-8154, United States. hcarlson@notes.cc.sunysb.edu

Molecular and Cellular Endocrinology
|March 17, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antipsychotic-Related Prolactin Levels and Sexual Dysfunction in Mentally Ill Youth: A 3-Month Cohort Study.

Journal of the American Academy of Child and Adolescent Psychiatry·2023
Same author

Gynaecomastia--pathophysiology, diagnosis and treatment.

Nature reviews. Endocrinology·2014
Same author

Osteoporosis and fracture risk in people with schizophrenia.

Current opinion in psychiatry·2012
Same author

Absorption of levothyroxine when coadministered with various calcium formulations.

Thyroid : official journal of the American Thyroid Association·2011
Same author

Approach to the patient with gynecomastia.

The Journal of clinical endocrinology and metabolism·2011
Same author

Colesevelam hydrochloride and lanthanum carbonate interfere with the absorption of levothyroxine.

Thyroid : official journal of the American Thyroid Association·2009
Same journal

Blood-based microRNAs as biomarkers of insulin resistance in childhood obesity: A systematic review and meta-analysis.

Molecular and cellular endocrinology·2026
Same journal

Female-specific metabolic genetic liability reveals a separable metabolic dimension of polycystic ovary syndrome.

Molecular and cellular endocrinology·2026
Same journal

The kisspeptin analog C6 elicits greater tachyphylaxis and transcriptional activation than kisspeptin-10 and -54.

Molecular and cellular endocrinology·2026
Same journal

G1 regulation of BK<sub>Ca</sub> channel leads to decreased migration of senescent pericytes and improved age-related hearing loss.

Molecular and cellular endocrinology·2026
Same journal

Maternal butyrate administration ameliorates fetal fatty liver and maternal metabolic alterations related to maternal obesity.

Molecular and cellular endocrinology·2026
Same journal

Retraction notice to " Steroid-induced oocyte maturation in Indian shad Tenualosa ilisha (Hamilton, 1822) is dependent on phosphatidylinositol 3 kinase but not MAP kinase activation" [Mol. Endocrinol. 390 (2014) 26-33].

Molecular and cellular endocrinology·2026
See all related articles

Luteinizing hormone/human chorionic gonadotropin (LH/hCG) receptors in the adrenal cortex explain some cases of hyperfunction. This finding suggests potential for spontaneous remission or treatment with GnRH-agonists for adrenal disorders.

Area of Science:

  • Endocrinology
  • Reproductive Biology
  • Oncology

Background:

  • Adrenal cortex hyperfunction can be linked to luteinizing hormone/human chorionic gonadotropin (LH/hCG) stimulation of steroid hormone production.
  • The presence of LH/hCG receptors in human adrenal tissues offers a new understanding of these clinical conditions.

Purpose of the Study:

  • To investigate the role of LH/hCG receptors in the adrenal cortex.
  • To explore the implications of these receptors for conditions like Cushing's syndrome and androgen excess.

Main Methods:

  • Demonstration of LH/hCG receptor presence in normal and abnormal human adrenal tissues.

Main Results:

  • LH/hCG receptors are present in various human adrenal tissues.

Related Experiment Videos

  • This receptor presence provides a novel explanation for adrenal hyperfunction.

    • Conclusions:

    • Adrenal LH/hCG receptor involvement should be considered in pregnant or post-menopausal patients with ACTH-independent Cushing's syndrome or androgen excess.
    • This discovery opens possibilities for spontaneous remission or GnRH-agonist therapy.
    • Further research is needed to define the receptor's role in normal and fetal adrenals and its activation in disease.