Related Experiment Video
Updated: Jul 16, 2026
Breath Collection from Children for Disease Biomarker Discovery
Published on: February 14, 2019
8-Isoprostane in nasally exhaled breath condensate in different pediatric lung diseases
P Latzin1, J Beck-Ripp, D Hartl
1Dr. von Haunersches Kinderspital, Ludwig-Maximilians-University, Lindwurmstr. 4, 80337 Munich, Germany.
Objective:
Increased levels of 8-isoprostane were found in various human lung diseases suggesting 8-isoprostane as a marker of pulmonary oxidative stress in vivo. The exact role in pediatric lung diseases has not been defined yet. The goal of this study was to clarify the role of 8-isoprostane in nasally exhaled breath condensate as possible marker of oxidative stress in children with different lung diseases.
Methods:
Levels of 8-isoprostane were measured in nasally exhaled breath condensate of 29 cystic fibrosis patients, 19 children with a history of wheezing episodes, 8 infants with acute respiratory tract infection and 53 healthy subjects using a specific enzyme immunoassay.
Results:
Levels of 8-isoprostane did neither discriminate between different disease groups nor correlate with lung function in cystic fibrosis patients.
Conclusions:
Levels of 8-isoprostane in nasally exhaled breath condensate do not reflect oxidative stress in children with different lung diseases.
