Related Experiment Video
Updated: Jul 16, 2026

Rat Burn Model to Study Full-Thickness Cutaneous Thermal Burn and Infection
Published on: August 23, 2022
Protective effect of complex antioxidant preparation containing vitamins and amino acids in rats with burn trauma
E V Mikhal'chik1, S M Titkova, M V Anurov
1Department of Molecular Biology, Department of Physiology, Russian State Medical University, Moscow. lemik@zmail.ru
Abstract:
Burn trauma increased blood chemiluminescence, while lipopolysaccharide in a dose of 1 mg/kg potentiated this effect, activated LPO, and decreased plasma antioxidant activity. In erythrocytes, superoxide dismutase activity increased, while activity of peroxide-utilizing enzymes decreased. Myeloperoxidase content increased in the lungs and epidermis. The preparation of alpha-tocopherol, selenium aspartate, and ubiquinone abolished the effect of lipopolysaccharide, but did not modulate the increase in chemiluminescence under the influence of this agent.

