Heart sensitivity to electrolyte composition of perfusion solution of rats after severe brain injury

The in vitro model of isovolumic beating heart revealed enhanced sensitivity of the hearts from rats survived severe brain injury to concentration of Ca(2+), Na(+), and H(+) ions in the perfusion solution. Inhibition of myocardial contractile function after trauma was accompanied by destruction signs in cardiomyocyte sarcolemma and mitochondrial dysfunction.