Related Experiment Video

Updated: Jul 16, 2026

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents
07:26

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents

Published on: July 14, 2021

Morphogenesis and variants of remodeling of atherosclerotic heart

L M Nepomnyashchikh1, V D Rozenberg

  • 1Department of General Pathology and Pathomorphology, Institute of Regional Pathology and Pathomorphology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk. pathol@soramn.ru

Bulletin of Experimental Biology and Medicine
|March 17, 2007
PubMed

Insights

The study reveals that dilatation remodeling in atherosclerotic hearts, particularly coronary arteries, leads to poor heart failure prognosis. Compensatory mechanisms like cardiomyocyte hypertrophy offer temporary functional support.

Area of Science:

  • Cardiovascular Pathology
  • Pathomorphology
  • Atherosclerosis Research

Background:

  • Atherosclerotic heart disease involves complex remodeling processes affecting cardiac structure and function.
  • Understanding the specific mechanisms of heart and coronary vessel remodeling is crucial for predicting disease outcomes.

Purpose of the Study:

  • To analyze the pathomorphological features of atherosclerotic heart remodeling.
  • To investigate the roles of dilatation and hypertrophic variants in disease progression.
  • To elucidate the structural mechanisms underlying cardiac and coronary vessel changes.

Main Methods:

  • Complex pathomorphological analysis.
  • Examination of 1000 autopsy cases.
  • Focus on heart and coronary vessel remodeling in atherosclerosis.

Main Results:

  • Predominant dilatation remodeling of the atherosclerotic heart and coronary arteries is associated with an unfavorable prognosis for heart failure.
  • Hypertrophic variants were also observed and analyzed.
  • Compensatory processes, including cardiomyocyte hypertrophy and collateral circulation, were identified.

Conclusions:

  • Dilatation variant remodeling significantly worsens the prognosis of heart failure in atherosclerotic conditions.
  • Adaptive mechanisms like cardiomyocyte hypertrophy and collateral circulation provide temporary compensation for cardiac functional insufficiency.

More Related Videos

Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure09:37

Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure

Published on: December 2, 2014

En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos08:57

En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos

Published on: July 27, 2022

Related Concept Videos

Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
Inflammation01:38

Inflammation

Overview
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...