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Updated: Jul 16, 2026

Metabolomic Analysis of Rat Brain by High Resolution Nuclear Magnetic Resonance Spectroscopy of Tissue Extracts
Published on: September 21, 2014
Alanine peak in central neurocytomas on proton MR spectroscopy
T Krishnamoorthy1, V V Radhakrishnan, B Thomas
1Department of Imaging Sciences and Interventional Radiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, 695011, India. b_krish1@yahoo.co.in
Introduction:
We present three consecutive patients with central neurocytoma in whom proton MRS demonstrated the presence of alanine.
Materials And Methods:
Three patients in the age range 24 to 30 years underwent MRI and proton MRS using a 1.5-T system. MRS was performed with the multivoxel PRESS sequence. All three patients underwent surgery and the diagnosis of central neurocytoma was established by histopathological examination and immunostaining.
Results:
With an echo time of 135 ms glycine, high choline, small NAA and alanine were observed in all three patients.
Conclusion:
Alanine may be observed in central neurocytomas as it is in meningiomas. Other spectral peaks such as those for glycine and NAA should help to identify this tumor correctly.
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