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[Eosinophilic dermatoses].

¹Klinik und Poliklinik für Dermatologie, Universitätsklinikum Carl Gustav Carus Dresden an der Technischen Universität Dresden, Fetscherstrasse 74, 01307 Dresden, Germany. Verena.Huebner@uniklinikum-dresden.de

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete

|March 17, 2007

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Eosinophilic granulocytes play key roles in immune responses and disease. Advances distinguish reactive eosinophilia from hypereosinophilic syndrome, guiding diagnosis and targeted therapies like monoclonal antibodies.

Area of Science:

Hematology
Immunology
Dermatology

Context:

Eosinophilic granulocytes (eosinophils) are crucial in immune responses, inflammation, and neoplastic processes.
Recent molecular pathophysiology advances aid in differentiating reactive (secondary) from clonal eosinophilia, including hypereosinophilic syndrome (HES).
Dermatological disorders frequently exhibit transient or persistent eosinophilia, often reactive.

Purpose:

To provide a clinical summary of dermatological disorders associated with reactive eosinophilia.
To highlight hypereosinophilic syndrome as a critical differential diagnosis in idiopathic eosinophilia.
To review emerging targeted therapies for eosinophilic disorders.

Summary:

This review details dermatological conditions linked to reactive eosinophilia.

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Hypereosinophilic syndrome, a form of idiopathic eosinophilia, frequently impacts organs like skin and heart, necessitating its consideration in differential diagnoses.

Therapeutic strategies now include monoclonal antibodies targeting specific molecules like IL-5 and CD52.

Impact:

Enhances understanding of eosinophil-related diseases, particularly in dermatology.
Facilitates accurate diagnosis by distinguishing reactive eosinophilia from HES.
Informs clinical practice regarding novel targeted treatments for eosinophilic disorders.