Related Experiment Video
Updated: Jul 16, 2026

Fluorescence Assays for the Study of Mycobacterium tuberculosis Interaction with the Immune Receptor SLAMF1
Published on: February 28, 2025
Host innate immune response to Mycobacterium tuberculosis
Kamlesh Bhatt1, Padmini Salgame
1Department of Medicine, Centre for Emerging Pathogens, UMDNJ-New Jersey Medical School, Newark, New Jersey 07101, USA.
Abstract:
This review focuses on recent progress in our understanding of Mycobacterium tuberculosis survival in macrophages, the interaction of M. tuberculosis with Toll-like receptors (TLRs) and the establishment of the link between innate and adaptive immunity, and TLRs and interferon-gamma-mediated antimicrobial pathways in macrophages. We also propose a paradigm that TLR2 signaling regulates the magnitude of the host Th1 response leading to either M. tuberculosis persistence and latent infection or replication and disease.
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