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Eye-Tracking Control to Assess Cognitive Functions in Patients with Amyotrophic Lateral Sclerosis

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Detecting neurobehavioral changes in amyotrophic lateral sclerosis.

Alison B Grossman¹, Susan Woolley-Levine, Walter G Bradley

¹Department of Neurology, University of Miami Miller School of Medicine, Miami, FL 33136, USA. agrossman@med.miami.edu

Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases

|March 17, 2007

Summary

Amyotrophic lateral sclerosis (ALS) patients frequently exhibit behavioral changes, particularly apathy, early in the disease. The Frontal Systems Behavior Scale (FrSBe) effectively detects these changes, suggesting a link between ALS and frontotemporal dementia (FTD).

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Area of Science:

Neurology
Neuropsychology
Behavioral Science

Background:

Cognitive impairment is recognized in Amyotrophic Lateral Sclerosis (ALS).
Behavioral abnormalities in ALS are less understood.
Frontotemporal Dementia (FTD) is characterized by behavioral disturbances.

Purpose of the Study:

To assess behavioral changes in ALS patients using the Frontal Systems Behavior Scale (FrSBe).
To investigate apathy, disinhibition, and executive dysfunction in ALS.
To explore the relationship between ALS and FTD.

Main Methods:

The study involved 45 patients diagnosed with ALS.
The Frontal Systems Behavior Scale (FrSBe) was administered to assess behavioral changes.
Correlations between apathy and verbal fluency were analyzed.

Main Results:

A high incidence of behavioral changes was observed in ALS patients.
Apathy was the most prominent behavioral change, appearing early and independent of mood.
Apathy correlated with verbal fluency deficits.

Conclusions:

The FrSBe is a valuable tool for identifying behavioral abnormalities in ALS.
Findings support a continuum between ALS and FTD, linked by behavioral disturbances.
Early detection of behavioral changes like apathy is crucial in ALS management.