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Inhibitory control in children with frontal infarcts related to sickle cell disease
Shawn E Christ1, Asif Moinuddin, Robert C McKinstry
1Department of Psychology, Washington University, St. Louis, MO, USA. research@shawnchrist.com
Insights
Children with frontal brain injury from sickle cell disease show impaired inhibitory control. This suggests frontal injury commonly affects this crucial cognitive function in pediatric populations.
Area of Science:
- Neuroscience
- Pediatric Neurology
- Cognitive Psychology
Background:
- Traumatic brain injury (TBI) is linked to inhibitory control deficits in children.
- Inhibitory control in pediatric cerebral infarction, particularly frontal, is less understood.
Purpose of the Study:
- To compare inhibitory control in children with frontal infarcts due to sickle cell disease (SCD) versus SCD children without infarcts.
- To investigate the impact of frontal cerebral infarction on inhibitory function in pediatric SCD.
Main Methods:
- A stimulus-response reversal task was used to assess inhibitory performance.
- Comparison between a group of children with frontal infarcts (SCD-FI) and a control group (SCD-Ctrl).
Main Results:
- Children with SCD-FI made significantly more accuracy errors during the inhibitory condition compared to SCD-Ctrl.
- This indicates a specific deficit in inhibitory control following frontal infarcts.
Conclusions:
- Frontal brain injury, even from conditions like SCD, leads to impaired inhibitory control in children.
- Findings support the broader conclusion that frontal injury commonly affects inhibitory control across pediatric populations.
Abstract:
Evidence from past studies indicates that children with traumatic brain injury experience difficulties with inhibitory control. Less is known about inhibitory control in children with frontal brain injury related to cerebral infarction. We compared the inhibitory performance of children with frontal infarcts related to sickle cell disease with that of a control group of children with sickle cell disease but no history of cerebral infarction. On a stimulus-response reversal task, children with frontal infarcts made significantly more accuracy errors in the inhibitory condition than controls. Findings from this study and from previous research suggest that impairments in inhibitory control are common following frontal injury in a range of pediatric populations.
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