Effects of blood pressure reduction on cardiovascular risk estimates in hypertensive postmenopausal women

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Published on: August 13, 2019

R A Preston1

  • 1Division of Clinical Pharmacology and Pharmacokinetics Clinical Research Center, Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.

Climacteric : the Journal of the International Menopause Society
|March 17, 2007
PubMed

Insights

Menopause increases hypertension risk, impacting cardiovascular health. Hormone therapy with drospirenone/17beta-estradiol effectively lowers blood pressure in postmenopausal women, aiding cardiovascular risk management.

Area of Science:

  • Cardiovascular Medicine
  • Endocrinology
  • Women's Health

Background:

  • Menopause is associated with a higher incidence of hypertension, contributing to cardiovascular risk in postmenopausal women.
  • Elevated blood pressure, even high-normal levels, significantly increases cardiovascular and target organ event risk.
  • Despite proven benefits, hypertension remains undertreated in a majority of patients.

Purpose of the Study:

  • To evaluate the effect of hormone therapy (drospirenone/17beta-estradiol) on blood pressure in hypertensive postmenopausal women.
  • To assess the potential of this hormone therapy in managing elevated blood pressure and associated cardiovascular risks.

Main Methods:

  • Clinical study involving hypertensive postmenopausal women.
  • Administration of drospirenone/17beta-estradiol alone or with antihypertensive drugs.
  • Monitoring of blood pressure changes.

Main Results:

  • Drospirenone/17beta-estradiol demonstrated a blood pressure-lowering effect in hypertensive postmenopausal women.
  • This effect was observed both as monotherapy and in combination with existing antihypertensive treatments.
  • The hormone therapy may offer an advantage for managing elevated blood pressure in this demographic.

Conclusions:

  • Hormone therapy with drospirenone/17beta-estradiol can effectively reduce blood pressure in hypertensive postmenopausal women.
  • This treatment approach may be beneficial for cardiovascular risk reduction in postmenopausal women with elevated blood pressure.
  • Early identification and management of elevated blood pressure are crucial for postmenopausal women's health.

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