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Related Concept Videos

Pharmaceutical Poisoning: Potential Scenarios01:26

Pharmaceutical Poisoning: Potential Scenarios

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Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
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Toxidromes: Clinical Features01:30

Toxidromes: Clinical Features

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Toxidromes are specific patterns of symptoms resulting from toxic substance exposure. They help in the identification and treatment of poisoning. The symptoms of each toxidrome group indicate poisoning by a certain class of chemicals or drugs.1. Sympathomimetic: Stimulates the sympathetic nervous system. Symptoms include agitation, increased heart rate (HR), blood pressure (BP), respiratory rate (RR), temperature, and pupil size. Drugs like cocaine and amphetamines, along with tremors and...
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Drug Toxicity: Overview01:00

Drug Toxicity: Overview

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Drug toxicity quantifies the harm a compound causes to an organism, varying by dose and potentially impacting whole systems or specific organs like the liver. Toxic reactions may arise from venomous insect or spider bites, with effects ranging from mild symptoms to severe outcomes such as brain damage or death. Common forms of acute poisoning include ethanol intoxication and overdose of pain or fever medications, with substances like GHB and heroin being particularly lethal at doses close to...
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Pharmaceutical Poisoning: Treatment Strategies01:26

Pharmaceutical Poisoning: Treatment Strategies

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Treatment strategies for poisoning are a critical aspect of emergency medicine, focusing on preventing the absorption of toxins and enhancing their elimination. When a poisoning incident occurs, the first response is to halt exposure and decontaminate the patient, particularly through gastrointestinal (GI) methods if the poison was ingested.Gastrointestinal Decontamination Techniques:Activated charcoal is the cornerstone of GI decontamination. It works through adsorption, binding the toxin to...
93
Prevention of Further Absorption of Poison01:14

Prevention of Further Absorption of Poison

1.3K
In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
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Anticholinesterase Agents: Poisoning and Treatment01:26

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Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.     
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
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Ruta Graveolens intoxication.

Chen-June Seak1, Chih-Chuan Lin

  • 1Department of Emergency Medicine, Chang Gung Memorial Hospital, Linkou, Taiwan.

Clinical Toxicology (Philadelphia, Pa.)
|March 17, 2007
PubMed
Summary
This summary is machine-generated.

Ruta Graveolens, a medicinal herb, can cause unintentional poisoning. This case highlights its potential for multi-organ toxicity, including heart, kidney, and blood clotting issues.

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Area of Science:

  • Herbal medicine
  • Toxicology
  • Cardiology

Background:

  • Ruta Graveolens is a medicinal herb used in Taiwan for heart protection.
  • Palpitations are a common cardiovascular symptom.

Observation:

  • A 78-year-old woman consumed Ruta Graveolens decoction for palpitations.
  • She developed bradycardia, acute renal failure with hyperkalemia, and coagulopathy.

Findings:

  • Ruta Graveolens consumption led to severe multi-organ toxicity.
  • Hemodialysis was required for hyperkalemia management.

Implications:

  • This case underscores the systemic toxicity of Ruta Graveolens.
  • Healthcare providers should be aware of potential adverse effects of herbal remedies.