Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

General background on the hypothalamic-pituitary-thyroid (HPT) axis.

R Thomas Zoeller1, Shirlee W Tan, Rochelle W Tyl

  • 1Biology Department, Morrill Science Center, University of Massachusetts-Amherst, Amherst, Massachusetts 01003, USA. tzoeller@bio.umass.edu

Critical Reviews in Toxicology
|March 17, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Letter to the editor regarding Hall et al. (2023): Fluoride exposure and hypothyroidism in a Canadian pregnancy cohort.

The Science of the total environment·2024
Same author

The Conflict between Regulatory Agencies over the 20,000-Fold Lowering of the Tolerable Daily Intake (TDI) for Bisphenol A (BPA) by the European Food Safety Authority (EFSA).

Environmental health perspectives·2024
Same author

The Price We Pay for the Convenience of Plastics.

Journal of the Endocrine Society·2024
Same author

European Medicines Agency Conflicts With the European Food Safety Authority (EFSA) on Bisphenol A Regulation.

Journal of the Endocrine Society·2023
Same author

A vision for safer food contact materials: Public health concerns as drivers for improved testing.

Environment international·2023
Same author

Evaluating adverse effects of environmental agents in food: a brief critique of the US FDA's criteria.

Environmental health : a global access science source·2023
Same journal

Microplastic trafficking in maternal-fetal system: a systematic review and quantitative profiling linking particle characteristics to developmental biology.

Critical reviews in toxicology·2026
Same journal

Addendum.

Critical reviews in toxicology·2026
Same journal

Inhalation exposure and health effects of copper particles in the context of occupational exposure limit derivation.

Critical reviews in toxicology·2026
Same journal

Screening for the ovarian toxicity of industrial chemicals - ovarian follicles and corpora lutea counts in rats, an inter- and intra-laboratory comparison.

Critical reviews in toxicology·2026
Same journal

Evaluation of the modes of action for key noncancer effects of 1,3-Butadiene: input from an independent expert panel to support derivation of data-derived extrapolation factors.

Critical reviews in toxicology·2026
Same journal

The effect of antioxidants on antineoplastic-induced male reproductive system damage: a systematic review of experimental studies.

Critical reviews in toxicology·2026
See all related articles

This review details the conserved vertebrate thyroid system, focusing on the hypothalamic-pituitary-thyroid (HPT) axis. It covers hormone synthesis, transport, receptors, and developmental roles, providing essential background for thyroid research.

Area of Science:

  • Endocrinology
  • Comparative Physiology
  • Toxicology

Background:

  • The thyroid system, particularly the hypothalamic-pituitary-thyroid (HPT) axis, is highly conserved across vertebrate species.
  • Thyroid hormones are crucial for metabolism, development, and numerous cellular functions.
  • Disruptions in the thyroid system can have significant health implications, especially during development.

Purpose of the Study:

  • To provide a comprehensive overview of the thyroid system and its components.
  • To establish foundational knowledge for understanding thyroid hormone action and regulation across vertebrates.
  • To highlight areas of potential disruption and research within thyroid endocrinology.

Main Methods:

  • Review of existing literature on thyroid hormone physiology and endocrinology.

Related Experiment Videos

  • Description of the structure, function, and regulation of the HPT axis.
  • Explanation of thyroid hormone synthesis, transport, metabolism, and receptor interactions.

    • Main Results:

    • Detailed outline of the HPT axis, thyroid gland function, and hormone synthesis.
    • In-depth analysis of thyroid hormone transport, cellular uptake, metabolism, and receptor mechanisms.
    • Exploration of nongenomic actions, compensatory mechanisms, and the role of thyroid hormone in mammalian development.

    Conclusions:

    • The thyroid system is complex and conserved, with critical roles in development and overall health.
    • Understanding the HPT axis and thyroid hormone action is essential for addressing endocrine disruptions.
    • This review serves as a foundational resource for further research on thyroid function in various vertebrate models.