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Related Experiment Videos

Zopiclone misuse: an update from Dublin.

Noreen Bannan1, Siobhan Rooney, John O'connor

  • 1Consultant Liaison Psychiatry, Connolly Hospital, Blanchardstown, County, Dublin, Ireland. bannann@eircom.net

Drug and Alcohol Review
|March 17, 2007
PubMed
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This study found that 23% of clients in a Dublin methadone program misused zopiclone, often alongside other drugs like benzodiazepines and heroin. Researchers recommend restricting zopiclone prescriptions for drug users.

Area of Science:

  • Pharmacology
  • Addiction Medicine
  • Clinical Toxicology

Background:

  • Zopiclone misuse is a growing concern within substance abuse treatment programs.
  • Detecting zopiclone misuse through its degradation product, 2-amino-5-chloropyridine (ACP), in urinalysis is a viable method.
  • Understanding the profile of zopiclone misusers is crucial for targeted interventions.

Purpose of the Study:

  • To determine the prevalence of zopiclone misuse among clients in a Dublin methadone maintenance program.
  • To characterize the profile of individuals misusing zopiclone.
  • To inform clinical practice regarding zopiclone prescribing in this population.

Main Methods:

  • Urine samples from 158 methadone maintenance program clients were analyzed for ACP, opiates, benzodiazepines, cocaine, alcohol, and cannabis.

Related Experiment Videos

  • Clients testing positive for ACP (n=37) were interviewed (n=23), with data from clinical records used for others (n=14).
  • Demographic, drug history, viral status, and urinalysis data were collected and analyzed.

    • Main Results:

    • The prevalence of zopiclone misuse, indicated by ACP detection, was 23% (37 out of 158 clients).
    • Zopiclone misuse occurred frequently in conjunction with other substances, notably benzodiazepines and heroin/opiates.
    • A detailed profile of zopiclone misusers was established, including their drug use patterns and demographics.

    Conclusions:

    • Zopiclone misuse is prevalent in this Dublin methadone maintenance program, often as part of polydrug use.
    • The findings suggest a need for stricter controls on zopiclone prescribing, particularly for individuals with a history of drug misuse.
    • Further research into the specific reasons for zopiclone misuse in this population may be warranted.