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Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier
Published on: April 26, 2016
Nanostructured lipid carriers-containing anticancer compounds: preparation, characterization, and cytotoxicity
Maria Luisa Bondì1, Emanuela Fabiola Craparo, Gaetano Giammona
1Istituto per lo Studio dei Materiali Nanostrutturati, sez. di Palermo, Consiglio Nazionale delle Ricerche, Palermo, Italy. marialuisa.bondi@ismn.cnr.it
Abstract:
This article describes the development of nanostructured lipid carriers (NLC) as colloidal carriers for two antitumor compounds that possess a remarkable antineoplastic activity. But their limited stability and low solubility in water could give a very low parenteral bioavailability. Results revealed an enhancement of the cytotoxicity effect of drug-loaded NLC on human prostate cancer (PC-3) and human hepatocellular carcinoma (HuH-6, HuH-7) cell lines with respect to that of both free drugs. Results of characterization studies strongly support the potential application of these drugs-loaded NLC as prolonged delivery systems for lipophilic drugs by several administration routes, in particular for intravenous administration.
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