Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Asthma-II: Pathophysiology and Classification

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

Asthma III: Clinical Manifestations

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...

Asthma-IV: Diagnostic and Management

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:

Asthma-III: Symptoms and Complications

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma

COPD: Pathogenesis and Clinical Features

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...

Asthma-I: Introduction

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

2025 Korean Guidelines for Cardiopulmonary Resuscitation: Part 2. Current status of cardiac arrest and the chain of survival.

Clinical and experimental emergency medicine·2026

Same author

2025 Korean Guidelines for Cardiopulmonary Resuscitation: Part 3. Adult basic life support.

Clinical and experimental emergency medicine·2026

Same author

2025 Korean Guidelines for Cardiopulmonary Resuscitation: Part 4. Adult advanced life support.

Clinical and experimental emergency medicine·2026

Same author

2025 Korean Guidelines for Cardiopulmonary Resuscitation: Part 5. Cardiac arrest in special circumstances.

Clinical and experimental emergency medicine·2026

Same author

2025 Korean Guidelines for Cardiopulmonary Resuscitation: Part 6. Post-cardiac arrest care.

Clinical and experimental emergency medicine·2026

Same author

2025 Korean Guidelines for Cardiopulmonary Resuscitation: Part 7. Pediatric basic life support.

Clinical and experimental emergency medicine·2026

Search research articles

Related Experiment Video

Updated: Jul 16, 2026

Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method

Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method

Published on: February 2, 2024

Comparison of Delta FVC (% decrease in FVC at the PC(20)) between cough-variant asthma and classic asthma.

Young Yoo¹, Jinho Yu, Sun Hee Lee

¹Department of Pediatrics, Korea University Anam Hospital, Seoul, Korea.

The Journal of Asthma : Official Journal of the Association for the Care of Asthma

|March 17, 2007

Summary

Cough-variant asthma (CVA) shows a lower maximal airway response compared to classic asthma (CA). This finding, based on methacholine challenge tests, suggests differences in airway hyperresponsiveness between asthma types.

More Related Videos

Phenotyping Mouse Pulmonary Function In Vivo with the Lung Diffusing Capacity

Phenotyping Mouse Pulmonary Function In Vivo with the Lung Diffusing Capacity

Published on: January 6, 2015

Related Experiment Videos

Last Updated: Jul 16, 2026

Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method

Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method

Published on: February 2, 2024

Phenotyping Mouse Pulmonary Function In Vivo with the Lung Diffusing Capacity

Phenotyping Mouse Pulmonary Function In Vivo with the Lung Diffusing Capacity

Published on: January 6, 2015

Area of Science:

Pulmonology
Allergy and Immunology
Pediatric Respiratory Medicine

Background:

Maximal airway response is a key indicator in asthma diagnosis and management.
The percentage decrease in forced vital capacity (FVC) at methacholine PC(20) (Delta FVC) is a proposed surrogate marker for maximal airway response.
Distinguishing between cough-variant asthma (CVA) and classic asthma (CA) is important for targeted treatment.

Purpose of the Study:

To compare the Delta FVC, a measure of maximal airway response, between children with CVA and those with CA.
To investigate potential differences in airway hyperresponsiveness between these two asthma phenotypes.

Main Methods:

Retrospective analysis of methacholine challenge test data.
Inclusion of 47 children diagnosed with CVA and 75 children with mild-severity CA.
Comparison of mean Delta FVC and methacholine PC(20) values between the CVA and CA groups.

Main Results:

The mean Delta FVC was significantly lower in the CVA group (14.7 +/- 3.4%) compared to the CA group (17.1 +/- 4.4%) (p = 0.001).
No significant difference was observed in methacholine PC(20) between the CVA and CA groups.
These findings indicate a reduced level of maximal airway response in children with CVA.

Conclusions:

Cough-variant asthma is associated with a lower maximal airway response compared to classic asthma.
Delta FVC may serve as a useful differential marker between CVA and CA.
Further research is warranted to explore the clinical implications of these differences in airway response.