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Updated: Jul 16, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Cutaneous granulomatous reaction to injectable hyaluronic acid gel: another case
Federico Bardazzi1, Alberto Ruffato, Angela Antonucci
1Department of Specialistic and Experimental Clinical Medicine, Division of Dermatology, University of Bologna, Italy.
Abstract:
We report a case of a granulomatous reaction in the melolabial folds, occurring 10 days after treatment with Restylane. The patient, who had previously been treated with the same product in the last 2 years without any adverse effect, developed an unusual early fibrotic reaction that we hypothesized related to hypersensitivity after repeated use. The lesions slowly disappeared with topical steroid therapy. An improved knowledge of the modality of these uncommon adverse effects is necessary to assess the long-term safety and efficacy of this product.
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