Related Experiment Video
Updated: Jul 16, 2026

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
Published on: March 17, 2016
Systematic review and meta-analysis of cyclodiene insecticides and breast cancer
Narges Khanjani1, Jan Lucas Hoving, Andrew Benjamin Forbes
1Department of Epidemiology & Preventive Medicine, Monash University, The Alfred Hospital, Melbourne, VIC, Australia. Narges.Khanjani@med.monash.edu.au
Abstract:
Cyclodienes are a group of organochlorine pesticides that have been the focus of increasing numbers of breast cancer etiology studies in recent years. The aim of this systematic review and meta-analysis was to summarize and pool the results of breast cancer and cyclodiene insecticide contamination studies. We used databases from 1966 to 7/2006 and included 21 case-control studies. Pooled odds ratios or differences in means as geometric means ratios were calculated. Meta-analysis of the chemicals did not reveal any statistically significant association except for heptachlor. The heterogeneity among the different studies and the methodology limitations are discussed.
Related Concept Videos
Positive Regulator Molecules
Inhibition of Cdk Activity
Mutagenicity and Carcinogenicity

