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Related Experiment Video

Updated: Jul 16, 2026

Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette Smoking

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Published on: August 6, 2013

Smoking cessation patterns in methadone-maintained smokers.

Michael D Stein¹, Bradley J Anderson, Raymond Niaura

¹Department of Medicine, Brown Medical School, Providence, RI, USA. mstein@lifespan.org

Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco

|March 17, 2007

Summary

Predictors of sustained smoking cessation in methadone patients include prior quit attempts, anticipating success, and consistent nicotine patch use. These factors can enhance future treatment strategies for smokers in treatment.

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Area of Science:

Addiction Medicine
Behavioral Psychology
Clinical Research

Background:

Smoking cessation is a significant challenge for individuals in methadone maintenance treatment.
Effective interventions are needed to improve long-term abstinence rates in this population.

Purpose of the Study:

To identify predictors of smoking cessation duration among smokers in methadone maintenance treatment.
To evaluate the association between baseline characteristics and intervention strategies with prolonged abstinence.

Main Methods:

Randomized clinical trial comparing two intervention arms: nicotine patch with comprehensive support versus nicotine patch with brief advice (4A's model).
383 smokers from methadone centers enrolled; 312 completed 6-month follow-up.
Multivariate analysis controlling for demographics, nicotine dependence, and symptoms.

Main Results:

Longer abstinence duration was associated with prior 24-hour quit attempts (OR=1.97), anticipating cessation success (OR=1.33), and higher percentage of nicotine patch use days (OR=2.78).
Past quit attempts, self-efficacy, and consistent nicotine replacement were significant predictors.

Conclusions:

Past quit attempts, self-efficacy, and consistent nicotine replacement therapy are key predictors of sustained smoking cessation in methadone-maintained smokers.
Future interventions should focus on these domains to improve treatment outcomes and long-term abstinence.