Related Experiment Video
Updated: Jul 16, 2026
10:33
Primed Mycobacterial Uveitis (PMU) as a Model for Post-Infectious Uveitis
Published on: December 17, 2021
Vitreous hemorrhage in multiple sclerosis-associated uveitis.
Natasa Vidovic Valentincic1, Aleksandra Kraut, Aniki Rothova
1University Medical Centre, Department of Ophthalmology, Ljubljana, Slovenia. vid.val@t-2.net
Ocular Immunology and Inflammation
|March 17, 2007
Summary
Vitreous hemorrhage (VH) occurred in 24% of patients with intermediate uveitis (IU) and multiple sclerosis (MS). VH can be an early sign of MS-associated uveitis, necessitating consideration of this diagnosis.
Area of Science:
- Ophthalmology
- Neurology
- Immunology
Background:
- Intermediate uveitis (IU) is an intraocular inflammatory condition.
- Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system.
- The association between IU and MS is recognized, but specific complications require further elucidation.
Observation:
- This case series reports on six patients with IU and MS who developed vitreous hemorrhage (VH).
- VH occurred in 24% of the studied IU and MS cohort.
- In 67% of cases, IU preceded the onset of MS, and VH appeared a median of five years after IU onset.
Findings:
- All patients exhibited peripheral phlebitis, ischemic retinal areas, and subretinal neovascularizations.
- VH resolved spontaneously in all cases, but two patients developed retinal detachment.
- Visual acuity outcomes varied significantly, with causes including optic neuritis, cystoid macular edema, and retinal detachment.
Implications:
- VH may be an early or presenting sign of MS-associated uveitis.
- Ophthalmologists should consider MS in patients presenting with IU and VH.
- Early diagnosis and management of MS-associated uveitis can potentially improve visual outcomes.
Related Concept Videos
01:25Glaucoma: Overview
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
01:19Multiple Sclerosis l: Introduction
Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
01:27Open Angle Glaucoma: Treatment
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...