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Published on: June 23, 2023
Decreased perfusion in young alcohol-dependent women as compared with age-matched controls
Camellia P Clark1, Gregory G Brown, Lisa T Eyler
1VA San Diego Healthcare System, Department of Psychiatry, University of California at San Diego, San Diego, California, USA. cclark@vapop.ucsd.edu
Aim:
To use the superior spatial resolution of magnetic resonance imaging (MRI) to examine differences in cerebral perfusion between young alcohol dependent and normal women.
Methods:
Eight alcohol dependent women and 8 controls (all ages 18-25) received single-slice resting perfusion-weighted MRI (directly proportional to brain blood flow), with slices located above the corpus callosum.
Results:
Alcohol-dependent women had decreased perfusion in prefrontal and left parietal regions.
Conclusions:
Reduced perfusion has not previously been reported in young, physically healthy alcohol dependent females, yet is consistent with previously reported decreased cerebral activity in alcohol dependence.
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