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Related Experiment Videos

[Pharmacotherapy--physostigmine administered post-operatively].

Ulrike Haase1, Ingrid Rundshagen

  • 1Charité--Universitätsmedizin Berlin, Klinik für Anästhesiologie und operative Intensivmedizin, Campus Mitte, Berlin, Germany. ulrike.haase@charite.de

Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS
|March 17, 2007
PubMed
Summary
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Monitoring depth of anesthesia utilizing a combination of electroencephalographic and standard measures.

Anesthesiology·2014

Central anticholinergic syndrome, a condition affecting mental status post-anesthesia, is effectively treated with physostigmine. This acetylcholinesterase inhibitor is also indicated for shivering, pain, and delirium.

Area of Science:

  • Anesthesiology and Pharmacology
  • Neuroscience

Context:

  • Central anticholinergic syndrome (CAS) presents with altered mental status after anesthesia.
  • Physostigmine is a key therapeutic agent for CAS.

Purpose:

  • To highlight the role of physostigmine in managing CAS.
  • To outline additional indications for physostigmine use.

Summary:

  • Physostigmine, a reversible acetylcholinesterase inhibitor, effectively treats CAS by increasing brain acetylcholine levels.
  • It is a first-line treatment for CAS and crosses the blood-brain barrier.

Impact:

  • Improves patient outcomes by managing post-anesthetic cognitive impairment.
  • Provides a therapeutic option for diverse clinical scenarios including shivering, pain, and delirium.

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