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Area map of mouse visual cortex.

Quanxin Wang1, Andreas Burkhalter

  • 1Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

The Journal of Comparative Neurology
|March 17, 2007
PubMed
Summary
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Mouse visual cortex organization is "simple" with a single V2-like area (LM) adjoining primary visual cortex (V1) laterally. However, it

Area of Science:

  • Neuroscience
  • Comparative Anatomy
  • Visual System Research

Background:

  • The organization of the mouse extrastriate cortex, specifically the areas adjacent to the primary visual cortex (V1), is debated.
  • Understanding this organization is crucial for insights into cortical evolution and development.

Purpose of the Study:

  • To resolve the controversy regarding the "simple" versus "complex" organization of the mouse extrastriate cortex.
  • To investigate the homology of visual areas across mammalian lineages.

Main Methods:

  • Utilized triple pathway tracing techniques.
  • Combined tracing with receptive field recordings for precise mapping.
  • Referenced visual maps against callosal landmarks within the same brain.

Related Experiment Videos

Main Results:

  • Identified 15 cortical fields receiving input from V1.
  • Found at least nine distinct areas with complete visual hemifield maps.
  • Determined that only the Lateral Medial (LM) area, homologous to V2, adjoins V1 laterally and shares the vertical meridian representation.

Conclusions:

  • Mouse visual cortex exhibits a "simple" organization laterally with a single V2-homologous area (LM).
  • The extrastriate cortex contains multiple distinct areas receiving direct V1 input, indicating a "complex" feature.
  • Suggests early evolution of numerous visual field maps and inheritance of homologous areas across mammals.