Related Experiment Videos

[Expression and significance of integrin alpha5, beta1 and E-CD in patients with non-small cell lung carcinoma]

Qi-Sen Guo1, Hui Jia, Ming-Yong Han

  • 1Department of Internal Medicine II, Shandong Tumor Hospital, Jinan 250117, China. guoqss@163.com

Zhonghua Zhong Liu Za Zhi [Chinese Journal of Oncology]
|March 21, 2007
PubMed
Abstract

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Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
Activation of Integrins01:15

Activation of Integrins

Integrins bind ligands and transmit information from outside the cell to inside or vice-versa through an "outside-in signaling" or "inside-out signaling."
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Integrins01:10

Integrins

Animal and protozoan cells do not have cell walls to help maintain shape and provide structural stability. Instead, these eukaryotic cells secrete a sticky mass of carbohydrates and proteins into the spaces between adjacent cells. This network of proteins and molecules is called an extracellular matrix or ECM.
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