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Related Experiment Video

Updated: Jul 16, 2026

Spinal Cord Neurons Isolation and Culture from Neonatal Mice

Spinal Cord Neurons Isolation and Culture from Neonatal Mice

Published on: July 11, 2017

[Spinal cord protection and opioids].

Manabu Kakinohana¹

¹Department of Anesthesiology, Faculty of Medicine, University of the Ryukyus, Okinawa.

Masui. the Japanese Journal of Anesthesiology

|March 21, 2007

Summary

Intrathecal morphine after aortic occlusion in rats caused spinal cord injury and ventral neuron degeneration. This highlights risks of morphine-induced paraplegia after thoracic aortic surgery.

Area of Science:

Neuroscience
Pharmacology
Spinal Cord Injury Research

Context:

Opioids are used for pain management, but potential neurotoxic effects require investigation.
Previous studies indicated opioid-induced brain damage in animals at high doses.
Recent findings suggest spinal cord toxicity from intrathecal morphine.

Purpose:

To investigate the neurotoxic effects of intrathecal morphine following ischemic injury in a rodent model.
To elucidate the mechanisms underlying morphine-induced spinal cord damage.
To raise awareness among anesthesiologists regarding potential morphine-induced paraplegia.

Summary:

Intrathecal morphine administration after short aortic occlusion in rats induced transient spastic paraparesis.
Histopathological analysis revealed IT morphine can cause spinal ventral neuron degeneration, even after brief ischemia.

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This degeneration is linked to N-methyl-D-aspartate receptor activation due to elevated glutamate release in cerebrospinal fluid.

Impact:

Highlights a potential risk of morphine-induced paraplegia in patients undergoing thoracic aortic surgery.
Emphasizes the need for careful selection of opioid analgesics in this patient population.
Informs clinical practice regarding the safe use of opioids in spinal cord injury contexts.