Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Halothane changes the relationships between lung resistances and lung volume.

M J Joyner1, D O Warner, K Rehder

  • 1Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota 55905.

Anesthesiology
|February 1, 1992
PubMed
Summary

Halothane anesthesia reduces airway resistance and tissue resistance dependence on lung volume during airway smooth muscle stimulation in dogs. This finding suggests halothane impacts respiratory mechanics under specific conditions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Driving performance of outpatients achieving discharge criteria after deep sedation is worse than these of their escort-driver: a prospective observational study on simulator.

Acta gastro-enterologica Belgica·2023
Same author

Cerebrovascular reactivity after cessation of menopausal hormone treatment.

Climacteric : the journal of the International Menopause Society·2019
Same author

Association between exposure to anaesthesia and surgery and long-term cognitive trajectories in older adults: report from the Mayo Clinic Study of Aging.

British journal of anaesthesia·2018
Same author

What do recent human studies tell us about the association between anaesthesia in young children and neurodevelopmental outcomes?

British journal of anaesthesia·2017
Same author

Postoperative delirium in elderly patients is associated with subsequent cognitive impairment.

British journal of anaesthesia·2017
Same author

Beta-Blockade and Response to Exercise: Influence of Training.

The Physician and sportsmedicine·2016

Area of Science:

  • Respiratory Physiology
  • Anesthesiology

Background:

  • Airway resistance and tissue resistance are influenced by lung volume.
  • The effect of halothane on these relationships, particularly during airway smooth muscle stimulation, requires further investigation.

Purpose of the Study:

  • To investigate how halothane affects the relationship between airway resistance, tissue resistance, and lung volume.
  • To determine if halothane alters these resistances by changing airway and tissue components.

Main Methods:

  • Mongrel dogs were used to examine pulmonary resistance components.
  • Measurements were taken at various positive end-expiratory pressure (PEEP) levels before and during halothane administration.
  • Experiments were conducted with both reduced and stimulated airway smooth muscle tone (vagotomy and vagus nerve stimulation - VNS).

Related Experiment Videos

Main Results:

  • Before halothane, airway resistance increased at low PEEP, exacerbated by VNS. Tissue resistance increased at low PEEP only during VNS.
  • Halothane had no significant effect on resistances without VNS.
  • During VNS, halothane significantly blunted increases in airway and tissue resistance as PEEP decreased.

Conclusions:

  • Halothane attenuates the increases in airway and tissue resistance associated with reduced lung volume during airway smooth muscle stimulation in dogs.
  • Under halothane anesthesia, moderate lung volume changes have minimal impact on airway and tissue resistances when airway smooth muscle is stimulated.