Related Experiment Video
Updated: Jul 16, 2026

A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood
Published on: April 28, 2016
Serum ghrelin changes in thyroid dysfunction
Abdolsamad Sadegholvad1, Mojhgan Afkhamizadeh, Gholamhossein Ranjbar-Omrani
1Endocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Background:
Thyroid dysfunction is associated with changes in the appetite. Ghrelin can regulate feeding behavior. The aim of this study was to evaluate whether ghrelin plays a role in the appetite changes in different states of thyroid dysfunction.
Methods:
The serum ghrelin levels were measured in 45 newly diagnosed hyperthyroid and 45 newly diagnosed hypothyroid patients before and after medical treatment. Forty-five healthy subjects were also studied as control group.
Results:
The ghrelin levels did not change significantly in patients with hyperthyroidism or hypothyroidism before and after the treatment. The ghrelin levels were not different from those of the control group.
Conclusion:
Ghrelin is not likely to be the primary determinant of appetite changes in thyroid dysfunction.
Related Concept Videos
Hyperthyroidism I: Introduction
Hypothyroidism II: Pathophysiology
Hyperthyroidism II: Pathophysiology
Graves Disease II: Pathophysiology
Synthesis and Regulation of Thyroid Hormones
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...
Graves' Disease I: Introduction