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Related Experiment Video

Updated: Jul 16, 2026

Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples
14:39

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Published on: April 21, 2014

Selective myocardial isolation and ventricular fibrillation.

Francisco J Chorro1, Estrella Blasco, Isabel Trapero

  • 1Service of Cardiology, Valencia University Clinic Hospital, Valencia, Spain. Francisco.J.Chorro@uv.es

Pacing and Clinical Electrophysiology : PACE
|March 21, 2007
PubMed
Summary

Radiofrequency (RF) lesions targeting specific heart zones did not prove essential for maintaining ventricular fibrillation (VF). However, isolating these zones often prevented VF induction within them, suggesting localized effects on arrhythmia susceptibility.

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Published on: February 17, 2023

Area of Science:

  • Cardiology
  • Electrophysiology
  • Medical Devices

Background:

  • Limited experimental data exists on radiofrequency (RF) lesions' impact on ventricular fibrillation (VF).
  • RF lesion-induced isolation of cardiac zones could reveal their role in sustaining VF.

Purpose of the Study:

  • To investigate whether specific myocardial zones are essential for ventricular fibrillation (VF) maintenance.
  • To evaluate the effect of selective RF lesions on VF inducibility in rabbit hearts.

Main Methods:

  • 31 Langendorff-perfused rabbit hearts underwent VF analysis before and after RF lesions.
  • Lesions targeted posterior septal/ventricular walls, anterior septal/ventricular walls, or the midseptal zone.
  • VF inducibility was assessed from within and outside isolated zones.

Main Results:

  • Complete isolation of targeted zones was achieved in several experiments.
  • VF was rarely induced within completely isolated zones (1/16 experiments).
  • Partial isolation prevented VF induction within the zone but not in surrounding myocardium.

Conclusions:

  • The studied septal and ventricular zones are not essential for maintaining VF.
  • Partial or total isolation of these zones generally prevented VF induction within them.
  • Myocardial regions outside the isolated zones remained capable of sustaining VF.