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The reactive metabolite target protein database (TPDB)--a web-accessible resource.

Robert P Hanzlik¹, Yakov M Koen, Bhargav Theertham

¹Department of Medicinal Chemistry, University of Kansas, Lawrence, KS 66045, USA. rhanzlik@ku.edu

BMC Bioinformatics

|March 21, 2007

Summary

A new database compiles information on protein targets of reactive metabolites from toxic chemicals. This resource aids in understanding how toxins damage cells by identifying common protein targets across different compounds.

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Area of Science:

Toxicology
Biochemistry
Proteomics

Background:

Toxic effects of organic compounds arise from reactive metabolites binding to cellular proteins.
Identifying common protein targets across multiple toxins is crucial for understanding cytotoxic mechanisms.
Existing literature on this topic is scattered, necessitating a centralized resource.

Purpose of the Study:

To create a comprehensive, searchable database of reactive metabolite target proteins.
To facilitate research into the mechanisms of toxicity caused by reactive metabolites.

Main Methods:

The Reactive Metabolite Target Protein Database (TPDB) was developed as a curated compilation of public information.
TPDB includes data on 18 well-studied toxic chemicals and drugs.
The database features search functionalities for authors, protein names, chemical compounds, species, tissues, and commonality searches.

Main Results:

TPDB provides a searchable compilation of protein targets for reactive metabolites.
Search results include detailed information, references, and links to other databases.
The database enables commonality searches across multiple chemicals.

Conclusions:

TPDB is a unique online resource for information on protein modification by reactive metabolites.
The database's comprehensiveness and searchability will aid in elucidating toxicity mechanisms.
TPDB is freely accessible online to researchers.