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Reactome: a knowledge base of biologic pathways and processes.

Imre Vastrik1, Peter D'Eustachio, Esther Schmidt

  • 1European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK. vastrik@ebi.ac.uk

Genome Biology
|March 21, 2007
PubMed
Summary
This summary is machine-generated.

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Reactome, a pathway database, infers reactions across species. This study validates inferred reactions in yeast and highlights Reactome

Area of Science:

  • Systems Biology
  • Bioinformatics
  • Computational Biology

Background:

  • Reactome is a curated online database for human biological pathways.
  • It provides computational infrastructure for analyzing biological reaction networks.

Purpose of the Study:

  • To infer equivalent biological reactions in nonhuman species using Reactome.
  • To assess the reliability of these inferred reactions for Saccharomyces cerevisiae.
  • To demonstrate Reactome's utility as a learning and computational tool for large-scale dataset interpretation.

Main Methods:

  • Utilized the Reactome database to computationally infer cross-species reaction equivalencies.
  • Validated inferred reactions by comparing them to known pathways in Saccharomyces cerevisiae.
  • Applied Reactome for the analysis and interpretation of microarray data.

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Main Results:

  • Successfully inferred equivalent reactions in multiple nonhuman species.
  • Presented reliability data for inferred reactions in Saccharomyces cerevisiae.
  • Demonstrated the practical application of Reactome in interpreting complex biological datasets.

Conclusions:

  • Reactome facilitates cross-species pathway inference and analysis.
  • Inferred reactions in Reactome show reliability for distantly related eukaryotes like yeast.
  • Reactome serves as a valuable resource for biological research and data interpretation.