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Updated: Jul 16, 2026
10:52
Sample Preparation for Mass Spectrometry-based Identification of RNA-binding Regions
Published on: September 28, 2017
The ring between ring fingers (RBR) protein family
Birgit Eisenhaber1, Nina Chumak, Frank Eisenhaber
1Research Institute of Molecular Pathology (IMP), Vienna, Austria. Birgit.Eisenhaber@imp.univie.ac.at
Genome Biology
|March 21, 2007
Summary
Ring between ring fingers (RBR)-domain proteins are crucial in eukaryotes, involved in protein interactions and E3 ubiquitin ligase functions. Their roles in diseases like Parkinson
Area of Science:
- Biochemistry
- Molecular Biology
- Genomics
Background:
- Ring between ring fingers (RBR)-domain proteins feature conserved cysteine and histidine residues, forming distinct N-RING and C-RING domains.
- The IBR domain's 3D structure remains unelucidated.
- Approximately 400 RBR-encoding genes exist in eukaryotes and viruses, absent in archaea and bacteria.
Purpose of the Study:
- To provide a comprehensive overview of RBR-domain containing proteins.
- To detail their subcellular localization, associated domains, functions, specificity, and regulatory mechanisms.
Main Methods:
- Phylogenetic analysis of RBR protein sequences to establish subfamily classifications.
- Review of existing literature on RBR protein structure, function, and disease associations.
Main Results:
- RBR proteins are classified into 15 major subfamilies based on sequence and architecture.
- RBR domains mediate protein-protein interactions; some function as E3 ubiquitin ligases.
- RBR proteins are implicated in neurodegenerative diseases (Parkinson's, Alzheimer's) and pathogen susceptibility.
Conclusions:
- RBR proteins represent a significant protein family with diverse roles in eukaryotic biology.
- Understanding RBR protein characteristics is vital for insights into disease mechanisms and host-pathogen interactions.
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