Related Experiment Video
Updated: Jul 16, 2026

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid
Published on: April 7, 2023
Impact of impaired fasting glucose and other metabolic factors on cognitive function in elderly people
P Di Bonito1, L Di Fraia, L Di Gennaro
1Department of Internal Medicine, S. Maria delle Grazie Pozzuoli Hospital, Via Domitiana Loc. La Schiana, 80078 Pozzuoli, Naples, Italy. diabetologia.po54@asl2.napoli.it
Aim:
The present study was undertaken to evaluate the impact of impaired fasting glucose (IFG), insulin resistance (IR) and hyperhomocysteinaemia (Hhcy) on cognitive function (CF) in a sample of non-diabetic elderly subjects.
Methods And Results:
One hundred and eighty-two non-diabetic subjects, aged > or = 65 years, without signs of previous stroke were included in the study. CF was evaluated by the Mini Mental State Examination (MMSE) score, corrected for age and education. Since diagnostic criteria for IFG have been recently lowered from 110 to 100 mg/dl, subjects were categorized according to old (IFG1997) and new (IFG2003) criteria. IR and Hhcy were defined by the upper quartile of insulin (11.0 UI/L) and Hcy (18.6 micromol/L) distribution, respectively. The frequency of IFG1997, Hhcy, and IR, but not of IFG2003, showed a linear trend across tertiles of MMSE (p<0.001). The odds ratio (95% CI) for impaired CF (MMSE<24.3) was 9.08 (2.97-27.74) for IFG1997, 3.66 (1.28-10.45) for Hhcy, 2.83 (1.25-6.37) for IR and 1.32 (0.61-2.89) for IFG2003.
Conclusions:
Our study shows that IFG1997, Hhcy and IR are powerful metabolic markers of impaired CF among elderly people.
More Related Videos
08:01A Method for Manipulating Blood Glucose and Measuring Resulting Changes in Cognitive Accessibility of Target Stimuli
Published on: August 12, 2016
12:59Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
Published on: July 5, 2017
Related Concept Videos
Overview of Carbohydrate Metabolism
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Alzheimer Disease l: Introduction
Diabetes: Symptoms, Diagnosis, and Complications
Cognitive Development During Adulthood
Drug Dosing: Geriatric Patients
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion