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Related Experiment Videos

Hyphenated spectroscopy as a polymorph screening tool.

Jaakko Aaltonen1, Clare J Strachan, Kati Pöllänen

  • 1Division of Pharmaceutical Technology, P.O. Box 56, 00014 University of Helsinki, Finland. jaakko.aaltonen@helsinki.fi

Journal of Pharmaceutical and Biomedical Analysis
|March 21, 2007
PubMed
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This study identified three solid forms of nitrofurantoin, including two anhydrates and one monohydrate. Combining near-infrared (NIR) and Raman spectroscopy effectively differentiates these polymorphs.

Area of Science:

  • Pharmaceutical Sciences
  • Solid-State Chemistry
  • Spectroscopy

Background:

  • Polymorphism significantly impacts drug stability and bioavailability.
  • Characterizing different solid forms is crucial for pharmaceutical development.
  • Nitrofurantoin serves as a model compound for polymorph screening.

Purpose of the Study:

  • To conduct a polymorph screen of nitrofurantoin.
  • To evaluate complementary spectroscopic techniques for solid form analysis.
  • To develop a rapid and comprehensive method for solid phase analysis.

Main Methods:

  • Crystallization of nitrofurantoin from acetone-water mixtures.
  • Analysis using near-infrared (NIR) spectroscopy, Raman spectroscopy, and terahertz pulsed spectroscopy (TPS).

Related Experiment Videos

  • Verification with X-ray powder diffraction (XRPD) and data analysis via principal component analysis (PCA).

    • Main Results:

    • Successfully crystallized two anhydrate forms (alpha and beta) and one monohydrate form (II).
    • Demonstrated the effectiveness of hyphenated NIR/Raman spectroscopy for solid form differentiation.
    • NIR spectroscopy distinguished between anhydrate/hydrate forms and intermolecular features.
    • Raman spectroscopy identified intramolecular alterations.

    Conclusions:

    • The combined NIR/Raman spectroscopic method provides a rapid and comprehensive approach for polymorph screening.
    • Complementary spectroscopic techniques coupled with multivariate analysis are powerful tools for solid form characterization.
    • This methodology aids in understanding and controlling the solid-state properties of pharmaceutical compounds.