Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gut microbiota: mining for therapeutic potential.

Ann M O'Hara1, Fergus Shanahan

  • 1Alimentary Pharmabiotic Centre, University College Cork, National University of Ireland, Cork, Ireland.

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
|March 21, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gut microbiome features associated with Bifidobacterium colonization predict personalized probiotic persistence patterns.

Nature communications·2026
Same author

Exploring the concept of bacterial memory.

Nature microbiology·2025
Same author

Toward a health-associated core keystone index for the human gut microbiome.

Cell reports·2025
Same author

Temporal stability and lack of variance in microbiome composition and functionality in fit recreational athletes.

Scientific reports·2025
Same author

Host-microbe multi-omics and succinotype profiling have prognostic value for future relapse in patients with inflammatory bowel disease.

Gut microbes·2025
Same author

International consensus statement on microbiome testing in clinical practice.

The lancet. Gastroenterology & hepatology·2024

The human gut microbiota influences intestinal health and immunity. Understanding host-microbe interactions is key to developing new therapies for inflammatory bowel disease.

Area of Science:

  • Microbiology and Immunology
  • Gastroenterology
  • Host-Microbe Interactions

Background:

  • The gut microbiota plays a crucial role in maintaining intestinal homeostasis and regulating mucosal immune responses.
  • In healthy individuals, the immune system maintains a balanced response to resident bacteria.
  • Dysregulated immune activation against gut bacteria can contribute to inflammatory bowel disease (IBD) in susceptible individuals.

Purpose of the Study:

  • To explore the role of the gut microbiota in intestinal homeostasis and immune regulation.
  • To investigate the potential of microbiota manipulation as a therapeutic strategy for inflammatory bowel disease.
  • To highlight the importance of understanding host-microbial molecular mechanisms for drug discovery.

Main Methods:

Related Experiment Videos

  • Review of current literature on host-microbe dialogue in health and disease.
  • Analysis of the role of pattern recognition receptors in innate host defense.
  • Discussion of modern molecular techniques for studying host-microbial interactions.

    • Main Results:

    • The gut microbiota provides regulatory signals influencing the intestinal epithelium and mucosal immunity.
    • Genetic susceptibility can lead to excessive immune responses against bacteria, promoting IBD pathogenesis.
    • The gut microbiota is a source of potential therapeutic metabolites.

    Conclusions:

    • Modulating the gut microbiota offers a promising therapeutic avenue for inflammatory bowel disease.
    • Elucidating the molecular mechanisms of host-microbial interactions is essential for developing novel 'bugs to drugs' therapies.
    • Further research into host-microbe dialogue is critical for advancing treatments for IBD and other diseases.