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Updated: Jul 16, 2026
A Biomimetic Model for Liver Cancer to Study Tumor-Stroma Interactions in a 3D Environment with Tunable Bio-Physical Properties
Published on: August 7, 2020
Expression of a liver-specific function by a hepatoblastoma cell line cocultured with three-dimensional
Takayuki Takei1, Shinji Sakai, Hiroyuki Ijima
1Department of Chemical Engineering, Faculty of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0385, Japan. ttakei@chem-eng.kyushu-u.ac.jp
Abstract:
A human hepatoblastoma cell line, Hep G2, showed albumin production activity, a hepatic function, when cocultured with three-dimensional endothelialized tubes in collagen gels. The albumin production rate of the collagen-based liver-like constructs increased with increasing length of the endothelialized tube in the construct.
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