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A rare gynecological case of paraneoplastic cerebellar degeneration discovered by FDG-PET
V Marchand1, J Graveleau, C Lanctin-Garcia
1Nuclear Medicine Division, Cancer Center, Neurology Unit, University Hospital, Saint-Herblain-Nantes, France. vimarchand@hotmail.com
Background:
PET/CT may be particularly useful to detect the primary cancer in paraneoplastic cerebellar degeneration (PCD) with anti-Yo which is most commonly associated with breast, ovarian and other gynecological cancers.
Case:
A 60-year-old woman developed a PCD associated with anti-Yo antibodies in serum and cerebrospinal fluid. Conventional imaging was negative. FDG-PET showed an abnormal hot spot in the right ovarian area associated with lombo aortic lymph nodes. The diagnosis was confirmed by surgery as an ovarian adenocarcinoma.
Conclusion:
In this case report, FDG-PET played a crucial role in detecting the unknown primary tumor in a patient with PCD.
