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Live-imaging of Breast Epithelial Cell Migration After the Transient Depletion of TIP60
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Notch1 intracellular domain suppresses APP intracellular domain-Tip60-Fe65 complex mediated signaling through

Sun-Yee Kim1, Mi-Yeon Kim, Jung-Soon Mo

  • 1Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Yongbong-dong, Buk-ku, Gwangju, 500-757, Republic of Korea.

Biochimica Et Biophysica Acta
|March 21, 2007
PubMed

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The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Notch Signaling Pathway03:14

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
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Role Of Notch Signalling In Intestinal Stem Cell Renewal

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Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
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