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Neurogenesis and major depression: implications from proteomic analyses of hippocampal proteins in a rat depression

Jun Mu1, Peng Xie, Ze-Song Yang

  • 1Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, The Key Laboratory of Diagnostic Medicine Designated by the Ministry of Education, Chongqing 400016, China.

Neuroscience Letters
|March 21, 2007
PubMed

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Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...