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Updated: Jul 16, 2026
07:29
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
Oxidized low-density lipoprotein: a double-edged sword on atherosclerosis
Bi-lian Yu1, Shui-ping Zhao, Xian-sheng Huang
1Department of Cardiology, The Second Xiangya Hospital of Central South University, Middle Ren-Min Road No. 139, Changsha, Hunan 410011, PR China.
Medical Hypotheses
|March 21, 2007
Summary
Oxidized low-density lipoprotein (oxLDL) plays a dual role in atherosclerosis. While high levels promote disease, low levels may offer protection by supporting cell health and cholesterol transport.
Area of Science:
- Cardiovascular Science
- Lipid Metabolism
- Atherosclerosis Research
Background:
- Atherosclerosis is linked to low-density lipoprotein (LDL) metabolism.
- Vascular cells oxidize LDL into highly reactive oxidized LDL (oxLDL).
- oxLDL is implicated in foam cell formation and proatherogenic processes.
Purpose of the Study:
- To explore the complex role of oxLDL in atherosclerosis.
- To investigate the potential atheroprotective effects of low oxLDL levels.
Main Methods:
- Review of existing evidence on oxLDL's effects.
- Analysis of oxLDL's involvement in cellular processes.
- Examination of oxLDL's impact on immunity and reverse cholesterol transport.
Main Results:
- Accumulating evidence suggests low oxLDL levels can be atheroprotective.
- Mechanisms include cytoprotection, immune modulation, and reverse cholesterol transport activation.
- High oxLDL levels remain atherogenic, contributing to foam cell formation.
Conclusions:
- Oxidized LDL (oxLDL) exhibits biphasic effects on atherosclerosis.
- oxLDL acts as a double-edged sword in cardiovascular disease progression.
- Further research is needed to fully elucidate oxLDL's therapeutic potential.
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