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Androgens and female sexual function.

Santiago Palacios1

  • 1Palacios Institute of Woman's Health, Madrid, Spain. ipalacios@institutopalacios.com

Maturitas
|March 21, 2007
PubMed
Summary
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Androgens, like testosterone, play a role in female sexual response. Clinical studies show testosterone patches are effective for hypoactive sexual desire with side effects similar to placebo.

Area of Science:

  • Endocrinology
  • Neuroscience
  • Women's Health

Background:

  • Androgens are crucial in various tissues and sexual response.
  • Ovaries are the primary source of androgens in reproductive-age women.
  • The brain, particularly the hypothalamus, expresses androgen receptors and influences sexual function.

Purpose of the Study:

  • To evaluate the role of androgens in female sexual response.
  • To assess the efficacy and safety of testosterone therapy for hypoactive sexual desire.

Main Methods:

  • Review of pivotal clinical trials, including The Intimate Study (SM1) and (SM2).
  • Analysis of data on testosterone patch efficacy for hypoactive sexual desire.
  • Evaluation of safety profiles compared to placebo.

Related Experiment Videos

Main Results:

  • Testosterone patches demonstrated clear and positive efficacy for hypoactive sexual desire.
  • Adverse events in testosterone treatment groups were comparable to the placebo group.
  • Androgen receptors are present in the human brain, suggesting a neurobiological basis for androgen action.

Conclusions:

  • Testosterone therapy, specifically the patch, is effective for hypoactive sexual desire in women.
  • Ongoing studies are investigating androgen therapy alone and in combination with estrogens for menopausal women.